WYE-687
mTOR 抑制剂
WYE-687
mTOR 抑制剂
WYE-687
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产品编号： CWR950005
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CAS号： 1062161-90-3
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分子式：C28H32N8O3
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分子量：528.61
英文别名：
Methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid
参考文献：
Huang, Shile., et al.: Cell Cycle, 11, 844 (2012); Yu, K., et al.: Cell Rsch., 15, 6232 (2009);
WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.
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