O2-乙烯基 1-(吡咯烷-1-基)偶氮-1-鎓-1,2-二氧化物
O2-乙烯基 1-(吡咯烷-1-基)偶氮-1-鎓-1,2-二氧化物
O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
O2-乙烯基 1-(吡咯烷-1-基)偶氮-1-鎓-1,2-二氧化物
O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
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产品编号： CVR500000
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CAS号： 179344-98-0
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分子式：C6H11N3O2
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分子量：157.17
英文别名：
V-PYRRO/NO
可溶性：
Ethanol
性状：
Pale Yellow Oil
SMILES：
C=CBr
参考文献：
Saavedra, J., et al.: J. Med. Chem., 40, 1947 (1997),
V-PYRRO/NO is a metabolically activated nitric oxide (NO) donor drug that can be used to selectively target NO delivery to the liver. The compound is metabolized by the liver, and spontaneously decomposes with a half-life of 3 seconds, liberating NO. Infusion of 30nmol/kg of V-PYRRO/NO in rats causes only a slight drop in blood pressure. At concentrations >100ug, V-PYRRO/NO increases hepatocyte viability against TNF-a-induced apoptosis by approximately 2-fold compared to cells not treated with this compound.
UV/Vis: lmax: 267nm e: 9,700
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