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(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔丁基(二甲基)硅基]氧}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七碳-12,16-二烯-5-酮
埃博霉素中间体;(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔丁基(二甲基)硅基]氧}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七碳-12,16-二烯-5-酮
(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadecyl-12,16-dien-5-one
  • 产品编号: CTR876675

  • CAS号: 193146-49-5

  • 分子式:C45H87NO5SSi3

  • 分子量:838.5

  • EINECES:248-597-9

英文别名:
-
可溶性:
Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Hexane, Methanol
性状:
Colourless Oil
SMILES:
C(C1=C(O)C(C(C)(C)C)=CC(CN2C(=O)N(CC3C=C(C(C)(C)C)C(O)=C(C(C)(C)C)C=3)C(=O)N(CC3C=C(C(C)(C)C)C(O)=C(C(C)(C)C)C=3)C2=O)=C1)(C)(C)C
参考文献:
Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999), Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical
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