PU-H71-d7 乙一水合物
6-氨基-8-[(6-碘-1,3-苯并二氧五环-5-基)硫]-N-(1-甲基乙基-d7)-9H-嘌呤-9-丙胺一水合物
PU-H71-d7 Hydrate
6-氨基-8-[(6-碘-1,3-苯并二氧五环-5-基)硫]-N-(1-甲基乙基-d7)-9H-嘌呤-9-丙胺一水合物
PU-H71-d7 Hydrate
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产品编号： CPR840122
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相关CAS号：1202865-65-3（未标记）
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分子式：C18H14D7In6O3S
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分子量：535.41
英文别名：
6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl-d7)-9H-purine-9-propanamine Hydrate
SMILES：
OCC(C(C(C(CO)O)O)O)=O
参考文献：
Gewirth, D.T., et al.: J. Med. Chem., 49, 381 (2006), Taldone, T., et al.: Bioorh. Med. Chem., 17, 2225 (2009),
Labelled PU-H71 (P840122). It is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease.
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