索非布韦
索非布韦
Sofosbuvir
索非布韦
Sofosbuvir
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产品编号： CPR839640
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CAS号： 1190307-88-0
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分子式：C22H29FN3O9P
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分子量：529.45
英文别名：
PSI-7977；GS-7977
SMILES：
Cl.[2H]C([2H])([2H])N[C@H]([C@@H](O)C1=CC=CC=C1)C([2H])([2H])[2H]
参考文献：
Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);
PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
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