匹伐他汀内酯-d5
匹伐他汀代谢表内标物；匹伐他汀-d5-内酯；匹伐他汀内酯-d5；尼伐他汀-d5
Pitavastatin-d5 Lactone
匹伐他汀代谢表内标物；匹伐他汀-d5-内酯；匹伐他汀内酯-d5；尼伐他汀-d5
Pitavastatin-d5 Lactone
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产品编号： CPR531022
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相关CAS号：141750-63-2（未标记）
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分子式：C25H17D5FNO3
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分子量：408.48
英文别名：
Nisvastatin-d5
熔点：
72-75°C
可溶性：
Chloroform, Ethyl Acetate
性状：
Off-White to Pale Yellow Solid
SMILES：
Cl.CC[C@@H]1CCN[C@H](C(N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@H](Cl)C)=O)C1
储存条件：
Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
参考文献：
Wang, J., et al.: Drug Metab. Dispos., 30, 1352 (2002), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Fujino, H., et al.: Xenobiotica, 34, 961 (2004),
A labelled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabolic activities and MDR1 transporting activity were investigated using human liver microsomes and MDR1-overexpressing LLC-GA5-COL150 cells
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