PD-169316
p38MAP激酶抑制剂；4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
PD-169316
p38MAP激酶抑制剂；4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
PD-169316
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产品编号： CPR217600
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CAS号： 152121-53-4
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分子式：C20H13FN4O2
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分子量：360.34
英文别名：
4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
参考文献：
Fu, Y. et al.: Bioche,. Biophys. Res. Comm., 310, 391 (2003); Krishnamoorthy, M. et al.: J. Biochem., 145, 177 (2009); Schwertz, H. et al.: Proteomics, 7, 24 (2007);
PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membrane tetraspanin. Studies show that PD 169316 reduces myocardial ischemia/reperfusion induced voltage-dependent anion channel(VDAC) phosphorylation
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