异烟肼-d4
异烟肼-d4
Isoniazid-d4
异烟肼-d4
Isoniazid-d4
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产品编号： CIR821452
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CAS号： 774596-24-6
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分子式：C6H3D4N3O
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分子量：141.16
英文别名：
4-(Pyridine-d4)carboxylic Acid Hydrazide; Isonicotinic Acid-d4 Hydrazide; 4-(Hydrazinocarbonyl)pyridine-d4; 4-(Pyridine-d4)carbonylhydrazine; 4-(Pyridine-d4)carboxylic Hydrazide; 4-(Pyridyl-d4)carbonylhydrazide; 5015 R.P.-d4; Armazid-d4; Armazide-d4; Atco
熔点：
159-1610C
可溶性：
DMSO, Methanol
性状：
White to Off-White Solid
SMILES：
CCOC(CC(SP(SC)(=O)OC)C(OCC)=O)=O
储存条件：
Refrigerator
参考文献：
Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)
Labelled Isoniazid. Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
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