伊洛前列素-d4
伊洛前列素-d4
Iloprost-d4
伊洛前列素-d4
Iloprost-d4
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产品编号： CIR267302
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CAS号： 1035094-10-0
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分子式：C22H28D4O4
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分子量：364.51
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EINECES：200-207-8
英文别名：
Endoprost-d4；Ciloprost-d4；Ilomedin-d4
SMILES：
IC1=CN(C2OC(CO)C(O)C2)C(=O)NC1=O
参考文献：
Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008); Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997); Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995);
A labelled synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
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