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2-(2-庚炔基硫)苯乙酸酯
2-(2-庚炔基硫)苯酚乙酸酯;2-(2-庚炔基硫)苯乙酸酯
APHS;2-(2-Heptynylthio)phenol Acetate
  • 产品编号: CHR288500

  • CAS号: 209125-28-0

  • 分子式:C15H18O2S

  • 分子量:262.37

英文别名:
APHS
参考文献:
Kalgutkar, A.S., et a.: Science, 280, 1268 (1998)
An O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and COX-2, with IC50 values of 17 and 0.8uM for human recombinant COX-1 and COX-2 respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1.
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