Begacestat
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Begacestat
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Begacestat
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产品编号： CGR797400
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CAS号： 769169-27-9
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分子式：C9H8ClF6NO3S2
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分子量：391.74
英文别名：
GSI-953
SMILES：
OC1C2C(=C(C(C)C)C(O)=C(O)C=2C=O)C=C(C)C=1C1C(C)=CC2C(=C(C=O)C(O)=C(O)C=2C(C)C)C=1O
参考文献：
van Es., et al.: Nature, 435, 959 (2005), Morohashi., et al.: J. Biol. Chem., 281, 1467 (2006), O'Neil., et al.: Neoplasia, 107, 781 (2006), Mayer, et al.: J. Med. Chem., 51, 7348 (2008), Martone, et al.: J. Pharmacol. Exp. Ther., 331, 598 (2009),
Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.
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