5-脱氢托伐普坦
托伐普坦杂质；5-脱氢托伐普坦
5-Dehydro Tolvaptan
托伐普坦杂质；5-脱氢托伐普坦
5-Dehydro Tolvaptan
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产品编号： CDR230350
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CAS号： 137973-76-3
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分子式：C26H23ClN2O3
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分子量：446.93
英文别名：
N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide; 1H-1-Benzazepine, Benzamide Deriv.; 7-Chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-Oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
熔点：
>118°C (dec.)
可溶性：
DMSO (Slightly), Methanol (Slightly)
性状：
白色固体
SMILES：
O=CC([C@@]1([C@]2(C[C@@H]([C@@H]3[C@]4(C)C(=CC(C=C4)=O)CC[C@H]3[C@@H]2CC1)O)C)O)=O
储存条件：
冷藏
参考文献：
Yin, L., et al.: Tetrahedron, Asym., 21, 2390 (2010); Torisawa, Y., et al.: Bioorg. Med. Chem. Lett., 17, 6455 (2007); Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999);
5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g
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