4,5-脱氢阿哌沙班
阿哌沙班杂质；4,5-脱氢阿哌沙班
4,5-Dehydro Apixaban
阿哌沙班杂质；4,5-脱氢阿哌沙班
4,5-Dehydro Apixaban
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产品编号： CDR229385
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CAS号： 1074549-89-5
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分子式：C25H23N5O4
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分子量：457.48
英文别名：
1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6,7-Dihydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxamide
熔点：
>252°C (dec.)
可溶性：
DMSO (Slightly), Methanol (Slightly, Heated)
性状：
灰白色至浅米色固体
SMILES：
CC1=C(C(OC(C)C)=O)C(C2=CC=CC([N+](=O)[O-])=C2)=C(C(OC2CN(C(C3=CC=CC=C3)C3=CC=CC=C3)C2)=O)C(N)=N1
储存条件：
冷藏
参考文献：
Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)
4,5-Dehydro Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
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