12-羟基奈韦拉平
奈韦拉平代谢物；12-羟基奈韦拉平
12-Hydroxy Nevirapine
奈韦拉平代谢物；12-羟基奈韦拉平
12-Hydroxy Nevirapine
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产品编号： CCR988365
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CAS号： 133627-24-4
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分子式：C15H14N4O2
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分子量：282.3
英文别名：
11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2’,3’-e][1,4] diazepin-6-one
熔点：
>184ºC (dec.)
可溶性：
DMSO (Slightly), Methanol (Slightly)
性状：
淡黄色固体
SMILES：
Cl.CNC(CC1CCCC1)C
储存条件：
冷藏
参考文献：
Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991), Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993), Guay, L.A., et al.: Lancet, 354, 795 (1999),
11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2’,3’-e][1,4]diazepin-6-one, is a metabolite of Nevirapine (N391275), which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. It is also an antiviral.
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